Search International and National Patent Collections

1. (WO2018204236) CRYSTALLINE FORMS OF A JAK INHIBITOR COMPOUND

Pub. No.:    WO/2018/204236    International Application No.:    PCT/US2018/030144
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Tue May 01 01:59:59 CEST 2018
IPC: C07D 471/04
A61K 31/4523
A61P 11/00
A61P 27/00
Applicants: THERAVANCE BIOPHARMA R&D IP, LLC
Inventors: DABROS, Marta
THALLADI, Venkat R.
NZEREM, Jerry
KLEINSCHEK, Melanie A.
CRATER, Glenn D.
Title: CRYSTALLINE FORMS OF A JAK INHIBITOR COMPOUND
Abstract:
The present invention provides crystalline hydrates of the oxalate and succinate salts of 5-ethyl-2-fluoro-4-(3-(5-(1-methylpiperidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl)phenol. The invention also provides pharmaceutical compositions comprising such crystalline hydrates, methods of using such crystalline hydrates to treat respiratory and other diseases, and processes useful for preparing such crystalline oxalate and succinate hydrates.