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1. (WO2018203833) METHODS FOR THE STIMULATION OF DENDRITIC CELL (DC) PRECURSOR POPULATION "PRE-DC" AND THEIR USES THEREOF

Pub. No.:    WO/2018/203833    International Application No.:    PCT/SG2018/050219
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Fri May 04 01:59:59 CEST 2018
IPC: A61K 39/39
A61K 31/7056
A61P 31/00
A61P 35/00
A61P 37/04
G01N 33/50
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventors: GINHOUX, Florent
SEE, Chi Ee Peter
Title: METHODS FOR THE STIMULATION OF DENDRITIC CELL (DC) PRECURSOR POPULATION "PRE-DC" AND THEIR USES THEREOF
Abstract:
The present invention relates to a method of treating or preventing an infection, a neoplastic disease or an immune-related disease in a subject in need thereof, the method comprising contacting a therapeutically effective or immuno-effective amount of an TLR9 agonist, specifically CpG oligodeoxynucleotide 2216 (CpG ODN), with a precursor dendritic cell (pre-DC), wherein the TLR9 agonist stimulates the pre-DC to secrete one or more cytokines such as TNF-alpha and IL-12p40, to thereby activate or increase the subject's immune response for treating or preventing the infection, the neoplastic disease or the immune-related disease. The present invention also relates to immunogenic or adjuvant compositions comprising the TLR9 agonist. A method of diagnosing a deficient immune system in a subject, comprising contacting a sample comprising pre-DC from the subject with one or more TLR 9 agonists and kits thereof are also disclosed.