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1. (WO2018203762) THE NEW USE OF 2-[(3Z)-6-FLUORO-2-METHYL-3-[(4-METHYLSULFINYLPHENYL) METHYLIDENE]INDEN-1 -YL] ACETIC ACID

Pub. No.:    WO/2018/203762    International Application No.:    PCT/PL2018/000036
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Thu Apr 12 01:59:59 CEST 2018
IPC: A61K 31/192
A61P 17/02
Applicants: WYŻSZA SZKOŁA MEDYCZNA W BIAŁYMSTOKU
Inventors: TOMULEWICZ, Mikołaj
Title: THE NEW USE OF 2-[(3Z)-6-FLUORO-2-METHYL-3-[(4-METHYLSULFINYLPHENYL) METHYLIDENE]INDEN-1 -YL] ACETIC ACID
Abstract:
The present invention relates to a new use of 2-[(3Z)-6- fluoro-2-methyl-3 - [(4-methylsulfinylpheny l)methylidene] inden- 1 - yl] acetic acid (sulindac) of the formula 1 to making of pharmaceutical preparations for the treatment of difficult healing different types of wounds in patients with diabetes. The medical use of 2-[(3Z)-6-fluoro-2-methyl-3-[(4- methylsulfinylphenyl)methylidene] inden- 1-yl] acetic acid (sulindac) of the formula 1 shown in the figure 1 for the preparation of pharmaceutical formulations for the treatment of difficult healing different types of wounds in patients with diabetes is disclosed. A pharmaceutical composition containing 2-[(3Z)-6-fluoro-2- methyl-3 - [(4-methylsulfinylphenyl) methylidene] inden- 1 -yl] acetic acid (sulindac), characterized in that it contains 2-[(3Z)-6-fluoro-2- methyl-3 - [(4-methylsulfinylphenyl) methylidene] inden- 1 -yl] acetic acid of formula 1 in an amount of 1 - 200 mg/ml.