Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018203751) THERAPEUTIC EFFECTS OF GUANABENZ TREATMENT IN VANISHING WHITE MATTER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/203751 International Application No.: PCT/NL2018/050293
Publication Date: 08.11.2018 International Filing Date: 04.05.2018
IPC:
A61K 31/00 (2006.01) ,A61K 31/4168 (2006.01) ,A61P 25/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4168
having a nitrogen atom attached in position 2, e.g. clonidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
STICHTING VUMC [NL/NL]; De Boelelaan 1117 1081 HV Amsterdam, NL
Inventors:
AN DER KNAAP, Margo Sientje; NL
HEINE, Vivi Majella; NL
ABBINK, Gertrude Elise Maria; NL
Agent:
JANSEN, CM.; V.O. Carnegieplein 5 2517 KJ Den Haag, NL
Priority Data:
17169488.804.05.2017EP
Title (EN) THERAPEUTIC EFFECTS OF GUANABENZ TREATMENT IN VANISHING WHITE MATTER
(FR) EFFETS THÉRAPEUTIQUES D'UN TRAITEMENT AU GUANABENZ DANS LA MALADIE DE DISPARITION DE LA SUBSTANCE BLANCHE
Abstract:
(EN) The invention relates to Guanabenz or an analogue thereof for use in the treatment and to methods of treatment of a subject that has vanishing white matter (VWM), comprising administering the compound Guanabenz or an analogue thereof to the subject in need thereof. Also provided are methods with which the success of a medical intervention in a subject with VWM can be determined. Such methods comprise quantifying the translocation of Bergmann glia into the molecular layer in the cerebellum in a suitable sample of the sub ject. The sample is typically a post mortem sample.
(FR) La présente invention concerne le guanabenz ou un analogue de celui-ci destiné à être utilisé dans le traitement et des procédés de traitement d'un sujet atteint de disparition de la substance blanche (VWM), comprenant l'administration du composé de guanabenz ou d'un analogue de celui-ci au sujet qui en a besoin. L'invention concerne également des procédés permettant de déterminer le succès d'une intervention médicale chez un sujet atteint de disparition de la substance blanche (VWM). De tels procédés comprennent la quantification de la translocation de la glie de Bergmann dans la couche moléculaire dans le cervelet dans un échantillon approprié du sujet. L'échantillon est typiquement un échantillon post mortem.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)