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|1. (WO2018203737) METHOD FOR EXTENDING HALF-LIFE OF PROTEIN|
OH, Su Kyung
LEE, Mi Jeong
|Title:||METHOD FOR EXTENDING HALF-LIFE OF PROTEIN|
The present invention relates to a method for extending the half-life of protein, the method comprising substituting one or more lysine residues in the amino acid sequence of protein, and to protein having an extended half-life. The protein for which lysine residues have been substituted according to the present invention persists in the body for an extended period of time, and exhibits excellent treatment results. The protein of the present invention is EGF, PDGFA and PDGFB, GM-CSF, FSH-alpha and FSH-beta, and ANGPT-1.