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1. (WO2018203737) METHOD FOR EXTENDING HALF-LIFE OF PROTEIN

Pub. No.:    WO/2018/203737    International Application No.:    PCT/KR2018/005239
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Sun May 06 01:59:59 CEST 2018
IPC: C07K 14/485
Applicants: UBIPORTEIN, CORP.
주식회사 유비프로틴
Inventors: BAEK, Kwang-Hyun
백광현
KIM, Kyunggon
김경곤
KIM, Myung-Sun
김명선
KIM, Hyeonmi
김현미
OH, Su Kyung
오수경
LEE, Mi Jeong
이미정
BAE, Sung-ryul
배성렬
Title: METHOD FOR EXTENDING HALF-LIFE OF PROTEIN
Abstract:
The present invention relates to a method for extending the half-life of protein, the method comprising substituting one or more lysine residues in the amino acid sequence of protein, and to protein having an extended half-life. The protein for which lysine residues have been substituted according to the present invention persists in the body for an extended period of time, and exhibits excellent treatment results. The protein of the present invention is EGF, PDGFA and PDGFB, GM-CSF, FSH-alpha and FSH-beta, and ANGPT-1.