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1. (WO2018203691) PYRIMIDINE DERIVATIVE COMPOUND, OPTICAL ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING TYRO 3 RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT

Pub. No.:    WO/2018/203691    International Application No.:    PCT/KR2018/005162
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Thu May 03 01:59:59 CEST 2018
IPC: C07D 403/14
A61K 31/506
A61K 31/4725
C07D 401/14
C07D 239/48
A61K 31/505
A23L 33/10
C07D 403/04
C07D 413/14
Applicants: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
한국화학연구원
Inventors: CHO, Sung Yun
조성윤
LEE, Chang Hoon
이창훈
MIN, Yong Ki
민용기
HWANG, Jong Yeon
황종연
Title: PYRIMIDINE DERIVATIVE COMPOUND, OPTICAL ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING TYRO 3 RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT
Abstract:
The present invention relates to a pyrimidine derivative compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a composition for preventing or treating cancer comprising the same as an active ingredient. The pyrimidine derivative compound, the optical isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has an excellent selective inhibitory effect especially against TYRO 3 among TAM receptor inhibitory effects, and thus can be used as an excellent composition of preventing or treating cancer without adverse effects resulting from the inhibition of Axl and Mer.