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1. (WO2018203582) METHOD FOR PROLONGING PROTEIN HALF-LIFE
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Pub. No.: WO/2018/203582 International Application No.: PCT/KR2017/004730
Publication Date: 08.11.2018 International Filing Date: 05.05.2017
IPC:
C07K 14/485 (2006.01) ,C07K 14/49 (2006.01) ,C07K 14/535 (2006.01) ,C07K 14/515 (2006.01) ,C07K 14/59 (2006.01) ,A61K 38/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
485
Epidermal growth factor (EGF) (urogastrone)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
49
Platelet-derived growth factor (PDGF)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
53
Colony-stimulating factor (CSF)
535
Granulocyte CSF; Granulocyte-macrophage CSF
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
515
Angiogenic factor; Angiogenin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
59
Follicle-stimulating hormone (FSH); Chorionic gonadotropins, e.g. HCG; Luteinising hormone (LH); Thyroid-stimulating hormone (TSH)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
주식회사 유비프로틴 UBIPORTEIN. CORP [KR/KR]; 경기도 성남시 분당구 판교역로 240, 삼환하이펙스 A동 518 A-518, Samwhan Hipex 240, Pangyoyeok-ro, Bundang-gu Seongnam-si Gyeonggi-do 13493, KR
Inventors:
백광현 BAEK, Kwang-Hyun; KR
김경곤 KIM, Kyunggon; KR
김명선 KIM, Myung-Sun; KR
김현미 KIM, Hyeonmi; KR
오수경 OH, Su Kyung; KR
이미정 LEE, Mi Jeong; KR
배성렬 BAE, Sung-ryul; KR
Agent:
이종승 LEE, Jong Seung; KR
Priority Data:
Title (EN) METHOD FOR PROLONGING PROTEIN HALF-LIFE
(FR) PROCÉDÉ POUR PROLONGER LA DEMI-VIE D'UNE PROTÉINE
(KO) 단백질 반감기를 증가시키는 방법
Abstract:
(EN) The present invention relates to a method for prolonging the half-life of a protein, comprising substituting at least one lysine residue present in an amino acid of the protein, or a protein with a prolonged half-life. A protein of the present invention, in which a lysine residue is substituted, remains in the human body for a long time and has excellent therapeutic effects. The protein of the present invention is EGF, PDGFA and PDGFB, GM-CSF, FSH-alpha and FSH-beta, and ANGPT-1.
(FR) La présente invention concerne un procédé pour prolonger la demi-vie d'une protéine, comprenant la substitution d'au moins un résidu lysine présent dans un acide aminé de la protéine, ou une protéine ayant une demi-vie prolongée. Une protéine selon la présente invention, dans laquelle un résidu lysine est substitué, reste dans le corps humain pendant une longue durée et a d'excellents effets thérapeutiques. La protéine selon la présente invention est EGF, PDGFA et PDGFB, GM-CSF, FSH-alpha et FSH-bêta, et ANGPT-1.
(KO) 본 발명은 단백질의 아미노산 서열에 존재하는 하나 이상의 라이신 잔기를 치환하는 것을 포함하여 단백질의 반감기를 증가시키는 방법 또는 반감기가 증가 된 단백질에 관한 것으로서, 본 발명의 라이신 잔기가 치환된 단백질은 인체 내에서 오랜 시간 동안 잔류하며 치료효과가 우수하다. 본 발명의 단백질은 EGF, PDGFA 및 PDGFB, GM-CSF, FSH-alpha 및 FSH-beta, 및 ANGPT-1 이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)