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|1. (WO2018203567) CYTOTOXICITY-INDUCING THERAPEUTIC AGENT|
|Applicants:||CHUGAI SEIYAKU KABUSHIKI KAISHA
HO, Shu Wen Samantha
LEE, Shuet Theng
|Title:||CYTOTOXICITY-INDUCING THERAPEUTIC AGENT|
The present invention provides multispecific antigen-binding molecules that comprise a first antigen-binding domain having RNF43-binding activity and a second antigen-binding domain having T cell receptor complex-binding activity, uses of such multispecific antigen-binding molecules, etc. The present inventors discovered novel multispecific antigen-binding molecules with excellent cellular cytotoxicity and high stability, which comprise a first antigen-binding domain having RNF43-binding activity and a second antigen-binding domain having T cell receptor complex-binding activity. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing RNF43, it is possible to produce novel pharmaceutical compositions comprising the multispecific antigen-binding molecules for treating or preventing various cancers.