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1. (WO2018203567) CYTOTOXICITY-INDUCING THERAPEUTIC AGENT

Pub. No.:    WO/2018/203567    International Application No.:    PCT/JP2018/017495
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Thu May 03 01:59:59 CEST 2018
IPC: C07K 16/30
A61K 39/395
A61P 35/00
Applicants: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventors: HOSHINO, Mayumi
KAWAI, Yumiko
ISHIGURO, Takahiro
AIDA, Satoshi
RUIKE, Yoshinao
HO, Shu Wen Samantha
LEE, Shuet Theng
Title: CYTOTOXICITY-INDUCING THERAPEUTIC AGENT
Abstract:
The present invention provides multispecific antigen-binding molecules that comprise a first antigen-binding domain having RNF43-binding activity and a second antigen-binding domain having T cell receptor complex-binding activity, uses of such multispecific antigen-binding molecules, etc. The present inventors discovered novel multispecific antigen-binding molecules with excellent cellular cytotoxicity and high stability, which comprise a first antigen-binding domain having RNF43-binding activity and a second antigen-binding domain having T cell receptor complex-binding activity. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing RNF43, it is possible to produce novel pharmaceutical compositions comprising the multispecific antigen-binding molecules for treating or preventing various cancers.