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1. (WO2018203559) PHARMACEUTICAL COMPOSITIONS FOR POLYGLUTAMINE DISEASES

Pub. No.:    WO/2018/203559    International Application No.:    PCT/JP2018/017448
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed May 02 01:59:59 CEST 2018
IPC: A61K 45/00
A61K 31/166
A61K 31/404
A61K 31/4162
A61K 31/4412
A61K 31/444
A61K 31/47
A61K 31/4709
A61K 31/496
A61K 31/5025
A61K 31/5377
A61P 21/02
A61P 25/00
A61P 25/14
A61P 43/00
C12Q 1/04
G01N 33/15
Applicants: KYOTO UNIVERSITY
国立大学法人京都大学
Inventors: HAGIWARA Masatoshi
萩原正敏
OKUNO Yukiko
奥野友紀子
Title: PHARMACEUTICAL COMPOSITIONS FOR POLYGLUTAMINE DISEASES
Abstract:
Provided are: pharmaceutical compositions for polyglutamine diseases and the uses thereof; methods for prevention, amelioration, progress-suppression and/or treatment of polyglutamine diseases using such pharmaceutical compositions; and a method for screening for a compound for polyglutamine diseases. One embodiment of the present invention pertains to a pharmaceutical composition that is for the prevention, amelioration, progress-suppression, and/or treatment of polyglutamine diseases, and that contains, as an active ingredient, at least one selected from the group consisting of vascular endothelial growth factor receptor (VEGFR) inhibitor compounds, compounds for inhibiting receptor tyrosine kinase (c-Met) encoded by c-Met gene, and compounds for inhibiting both VEGFR and c-Met. Another embodiment of the present invention pertains to a method for screening for a substance that has an effect on the formation of a polyglutamine aggregate, the method comprising a step for measuring, as an indicator of polyglutamine aggregates formed in a culture solution in which cells having introduced therein an expression system that expresses polyglutamine fused with a reporter protein have been cultured, a signal of the reporter protein present in a putative somatic region including a cell nucleus.