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1. (WO2018203545) METHOD FOR PREDICTING AND EVALUATING THERAPEUTIC EFFECT IN DISEASES RELATED TO IL-6 AND NEUTROPHILS

Pub. No.:    WO/2018/203545    International Application No.:    PCT/JP2018/017374
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed May 02 01:59:59 CEST 2018
IPC: C12Q 1/68
A61K 39/395
A61K 45/00
A61P 9/10
A61P 25/00
C12N 15/09
C07K 16/28
Applicants: NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY
国立研究開発法人国立精神・神経医療研究センター
CHUGAI SEIYAKU KABUSHIKI KAISHA
中外製薬株式会社
Inventors: MATSUOKA, Takako
松岡 貴子
ARAKI, Manabu
荒木 学
YAMAMURA, Takashi
山村 隆
Title: METHOD FOR PREDICTING AND EVALUATING THERAPEUTIC EFFECT IN DISEASES RELATED TO IL-6 AND NEUTROPHILS
Abstract:
It became clear that the therapeutic effect of an IL-6 inhibitor in diseases related to IL-6 and neutrophils can be predicted using the expression level of neutrophil-related genes as an indicator. It also became clear that an IL-6 inhibitor is effective in the treatment of diseases related to IL-6 and neutrophils in patients having a high expression level of neutrophil-related genes. The present invention provides a method for selecting cases of diseases related to IL-6 and neutrophils in which treatment by an IL-6 inhibitor will be effective and carrying out effective treatment of patients having diseases related to IL-6 and neutrophils in whom the expression level of neutrophil-related genes is high.