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1. (WO2018203525) PROCESS OF PREPARING IOSIMENOL
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Pub. No.: WO/2018/203525 International Application No.: PCT/JP2018/017192
Publication Date: 08.11.2018 International Filing Date: 27.04.2018
IPC:
C07C 231/12 (2006.01) ,C07C 231/14 (2006.01) ,C07C 231/24 (2006.01) ,C07C 237/46 (2006.01) ,C07D 317/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
231
Preparation of carboxylic acid amides
12
by reactions not involving the formation of carboxamide groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
231
Preparation of carboxylic acid amides
14
by formation of carboxamide groups together with reactions not involving the carboxamide groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
231
Preparation of carboxylic acid amides
22
Separation; Purification; Stabilisation; Use of additives
24
Separation; Purification
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
28
having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
46
having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
10
not condensed with other rings
14
with substituted hydrocarbon radicals attached to ring carbon atoms
28
Radicals substituted by nitrogen atoms
Applicants:
OTSUKA PHARMACEUTICAL CO., LTD. [JP/JP]; 2-9, Kanda Tsukasa-machi, Chiyoda-ku, Tokyo 1018535, JP
Inventors:
MALINAK, Jiri; CZ
HLAVACEK, Ivan; CZ
ZAHRADNIK, Petr; CZ
Agent:
YAMAO, Norihito; JP
SHINAGAWA, Hisatoshi; JP
Priority Data:
62/492,60001.05.2017US
Title (EN) PROCESS OF PREPARING IOSIMENOL
(FR) PROCÉDÉ DE PRÉPARATION D'IOSIMÉNOL
Abstract:
(EN) The present invention relates to a 5-step process for preparing iosimenol starting from ammonium 3-amino-5-(aminocarbonyl)benzoate which is first converted to 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoic acid using sodium iodine dichloride (NaICl2). The present invention further relates to processes for purifying iosimenol.
(FR) La présente invention concerne un procédé en 5 étapes pour la préparation d'iosiménol à partir d'ammonium 3-amino-5-(aminocarbonyle)benzoate qui est d'abord converti en acide 3-amino-5-(aminocarbonyle)-2,4,6-triiodobenzoïque à l'aide de dichlorure d'iode sodique (NaICl2). La présente invention concerne en outre des procédés de purification d'iosiménol.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)