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1. (WO2018203256) TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES

Pub. No.:    WO/2018/203256    International Application No.:    PCT/IB2018/053047
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Thu May 03 01:59:59 CEST 2018
IPC: C07D 401/04
C07D 401/14
C07D 405/04
A61K 31/506
A61P 35/00
Applicants: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: DE VIVO, Marco
GANESAN, Anand
ORTEGA MARTÍNEZ, Jose Antonio
JAHID, Sohail
Title: TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES
Abstract:
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.