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Pub. No.:    WO/2018/203219    International Application No.:    PCT/IB2018/052989
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Tue May 01 01:59:59 CEST 2018
IPC: A61K 45/06
A61K 31/18
A61K 31/44
A61K 31/4523
A61K 31/519
A61K 31/5377
A61P 35/00
Applicants: NOVARTIS AG
Inventors: COOKE, Vesselina
The present invention relates to a pharmaceutical combination comprising (a) a Raf inhibitor as defined herein, or a pharmaceutically acceptable salt thereof and (b) a MEK inhibitor, particularly trametinib, particularly for use in the treatment of a proliferative disease. This invention also relates to uses of such combination for preparation of a medicament for the treatment of a proliferative disease; methods of treating a proliferative disease in a subject in need thereof comprising administering to said subject a jointly therapeutically effective amount of said combination; use of such combination for the treatment of proliferative disease; pharmaceutical compositions comprising such combination and commercial packages thereto.