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1. (WO2018203076) MODIFIED MICROORGANISMS AND METHODS FOR PRODUCTION OF BRANCHED C5 CARBON COMPOUNDS
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Pub. No.: WO/2018/203076 International Application No.: PCT/GB2018/051196
Publication Date: 08.11.2018 International Filing Date: 03.05.2018
IPC:
C12N 1/16 (2006.01) ,C12P 7/16 (2006.01) ,C12P 7/46 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
16
Yeasts; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
04
acyclic
16
Butanols
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
40
containing a carboxyl group
44
Polycarboxylic acids
46
Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
Applicants:
GRADLEY, Michelle [GB/GB]; GB
Inventors:
GRADLEY, Michelle; GB
Agent:
JAPPY, John; GB
Priority Data:
1707034.303.05.2017GB
Title (EN) MODIFIED MICROORGANISMS AND METHODS FOR PRODUCTION OF BRANCHED C5 CARBON COMPOUNDS
(FR) MICRO-ORGANISMES MODIFIÉS ET PROCÉDÉS DE PRODUCTION DE COMPOSÉS CARBONÉS EN C5 RAMIFIÉS
Abstract:
(EN) The present invention relates to the engineering of organisms to imbue or enhance the ability to convert central metabolic intermediates (acetyl CoA, pyruvate) into 2- methyl succinic acid and other important chemicals, using novel, unnatural pathways. The option to use acetate provided either endogenously or exogenously in place of, or as a source of acetyl CoA is also expressly included.
(FR) La présente invention concerne l'ingénierie d'organismes pour imprégner ou améliorer la capacité de convertir des intermédiaires métaboliques centraux (acétyl CoA, pyruvate) en acide 2-méthyl succinique et d'autres produits chimiques importants, à l'aide de nouvelles voies, non naturelles. L'option de l'utilisation d'acétate fournit soit de manière endogène, soit de manière exogène à la place, ou en tant que source d'acétyl-CoA, est également expressément incluse.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)