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1. (WO2018203059) STABLE INSULIN FORMULATIONS

Pub. No.:    WO/2018/203059    International Application No.:    PCT/GB2018/051177
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Fri May 04 01:59:59 CEST 2018
IPC: A61K 33/30
A61K 38/28
A61K 47/12
A61K 47/18
A61K 47/26
A61K 9/08
A61P 3/10
Applicants: ARECOR LIMITED
Inventors: JEZEK, Jan
GERRING, David
HOWELL, Sarah
ZAKRZEWSKI, Leon
Title: STABLE INSULIN FORMULATIONS
Abstract:
The present invention relates inter alia to an aqueous liquid pharmaceutical formulation comprising: (i) an insulin compound; (ii) ionic zinc; (iii) a zinc binding species at a concentration of 1 mM or more selected from species having a logK with respect to zinc ion binding in the range 4.5-10 at 25 °C; (iv) a zinc binding species selected from species having a logK with respect to zinc ion binding of more than 12.3 at 25 °C at a concentration of less than about 0.3 mM; and (v) a non-ionic surfactant. It also provides related methods, uses and pharmaceutical compositions.