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1. (WO2018202910) COMBINATION OF ANTIBIOTIC AND BCL-2 INHIBITOR AND USES THEREOF
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Pub. No.: WO/2018/202910 International Application No.: PCT/EP2018/061694
Publication Date: 08.11.2018 International Filing Date: 07.05.2018
IPC:
A61K 45/06 (2006.01) ,A61K 31/496 (2006.01) ,A61K 31/65 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/475 (2006.01) ,A61K 31/573 (2006.01) ,A61K 31/675 (2006.01) ,A61K 31/704 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
65
Tetracyclines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
475
having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57
substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573
substituted in position 21, e.g. cortisone, dexamethasone, prednisone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
704
attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
Applicants:
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA [IT/IT]; Via Morego, 30 16163 Genova, IT
IEO-ISTITUTO EUROPEO DI ONCOLOGIA [IT/IT]; Via Filodrammatici, 10 20121 Milano, IT
Inventors:
RAVA', Micol; IT
D'ANDREA, Aleco; IT
AMATI, Bruno; IT
Agent:
CAPASSO, Olga; IT
TRILLAT, Anne-Cécile; IT
TURRI, Elisa; IT
Priority Data:
17169829.305.05.2017EP
18154368.731.01.2018EP
Title (EN) COMBINATION OF ANTIBIOTIC AND BCL-2 INHIBITOR AND USES THEREOF
(FR) COMBINAISON D'UN ANTIBIOTIQUE ET D'UN INHIBITEUR DE BCL-2 ET UTILISATIONS CORRESPONDANTES
Abstract:
(EN) The present invention relates to the therapeutic use of a combination of at least one mitochondrially-targeted antibiotic and at least one inhibitor of BCL-2 for use in the treatment of MYC/BCL2 double positive B-cell lymphomas and relative compositions.
(FR) La présente invention concerne l'utilisation thérapeutique d'une combinaison d'au moins un antibiotique ciblant les mitochondries et d'au moins un inhibiteur de BCL-2 destiné à être utilisé dans le traitement des lymphomes B à double liaison MYC/BCL2, ainsi que des compositions associées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)