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1. (WO2018202889) TRANSIENT DISRUPTION OF THE BLOOD-RETINAL BARRIER OF A HUMAN AND USES THEREOF FOR TREATING A RETINA DISORDER
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Pub. No.: WO/2018/202889 International Application No.: PCT/EP2018/061592
Publication Date: 08.11.2018 International Filing Date: 04.05.2018
IPC:
A61N 7/00 (2006.01) ,A61K 9/00 (2006.01) ,A61P 27/02 (2006.01) ,A61F 9/007 (2006.01) ,A61K 49/22 (2006.01) ,A61K 38/00 (2006.01) ,A61F 9/00 (2006.01) ,A61M 37/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
N
ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7
Ultrasound therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
[IPC code unknown for A61F 9/07]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
22
Echographic preparations; Ultrasound imaging preparations
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
9
Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
37
Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Applicants:
SORBONNE UNIVERSITE [FR/FR]; 21 rue de l’Ecole de Médecine 75006 Paris, FR
ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS [FR/FR]; 3 avenue Victoria 75004 PARIS, FR
Inventors:
CARPENTIER, Alexandre; FR
Agent:
CABINET BECKER ET ASSOCIES; 25, rue Louis le Grand 75002 PARIS, FR
Priority Data:
17305502.104.05.2017EP
Title (EN) TRANSIENT DISRUPTION OF THE BLOOD-RETINAL BARRIER OF A HUMAN AND USES THEREOF FOR TREATING A RETINA DISORDER
(FR) PERTURBATION TRANSITOIRE DE LA BARRIÈRE HÉMATO-RÉTINIENNE D'UN ÊTRE HUMAIN ET SES UTILISATIONS POUR LE TRAITEMENT D'UN TROUBLE RÉTINIEN
Abstract:
(EN) The present invention relates to an ultrasound contrast agent for use in treating a retina disorder by transiently disrupting the blood-retinal barrier (BRB) of a human, wherein the ultrasound contrast agent is administered just before and/or during the application, to the retina of the human, of an unfocused ultrasound (US) beam. The present invention further relates to a therapeutically active agent for use in treating a retina disorder in a human, wherein the therapeutically active agent is to be delivered in combination with an ultrasound contrast agent, which is administered before and/or during the application, to the retina of the human, of an unfocused ultrasound (US) beam in order to transiently disrupting the blood-retinal barrier (BRB) of the human, to allow the therapeutically active agent to cross the BRB and to target the retina. The present invention also relates to an eye ultrasound delivery device that may be used to treat a retina disorder.
(FR) La présente invention concerne un agent de contraste ultrasonore destiné à être utilisé dans le traitement d'un trouble rétinien par perturbation de manière transitoire de la barrière hémato-rétinienne (BHR) d'un être humain, l'agent de contraste ultrasonore étant administré juste avant et/ou pendant l'application, à la rétine de l'être humain, d'un faisceau ultrasonore non focalisé (US). La présente invention concerne en outre un agent thérapeutiquement actif destiné à être utilisé dans le traitement d'un trouble rétinien chez un être humain, l'agent thérapeutiquement actif devant être administré en combinaison avec un agent de contraste ultrasonore, qui est administré avant et/ou pendant l'application, à la rétine de l'être humain, d'un faisceau ultrasonore non focalisé (US) afin de perturber de manière transitoire la barrière hémato-rétinienne (BHR) de l'être humain, pour permettre à l'agent thérapeutiquement actif de traverser le BHR et de cibler la rétine. La présente invention concerne également un dispositif d'administration d'ultrasons à l'œil qui peut être utilisé pour traiter un trouble rétinien.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)