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1. (WO2018202876) SECRETION-COMPETENT MUTEINS OF THE HUMAN IL-27 ALPHA-SUBUNIT

Pub. No.:    WO/2018/202876    International Application No.:    PCT/EP2018/061561
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Sat May 05 01:59:59 CEST 2018
IPC: C07K 14/54
A61K 38/20
Applicants: TECHNISCHE UNIVERSITAET MUENCHEN
Inventors: FEIGE, Matthias
MUELLER, Stephanie
Title: SECRETION-COMPETENT MUTEINS OF THE HUMAN IL-27 ALPHA-SUBUNIT
Abstract:
The present invention refers to a secretion-competent mutein of the α-subunit of human Interleukin 27 and to a human heterodimeric Interleukin 27. The present invention further refers to a nucleic acid molecule comprising a nucleotide sequence encoding a secretion- competent mutein of the α-subunit of human Interleukin 27 or the human heterodimeric Interleukin 27, to a host cell containing a nucleic acid molecule comprising a nucleotide sequence encoding a secretion-competent mutein of the α-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention also refers to an immune modulator comprising a secretion-competent mutein of the α-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27, to the respective use thereof as well as to a method of producing saidsecretion-competent muteins and to a secretion-incompetent mutein of the α-subunit of mouse Interleukin 27and a secretion-competent mutein of the β-subunit of mouse Interleukin 27.