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1. (WO2018202783) STERILE AQUEOUS OPHTHALMIC SOLUTION CONTAINING N-(N-ACETYLCYSTEINYL)-CHITOSAN FOR TREATING NON-INFECTIOUS CORNEAL DISORDERS
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Pub. No.: WO/2018/202783 International Application No.: PCT/EP2018/061367
Publication Date: 08.11.2018 International Filing Date: 03.05.2018
IPC:
A61K 9/00 (2006.01) ,A61K 51/06 (2006.01) ,A61K 47/61 (2017.01) ,A61P 27/02 (2006.01) ,A61P 27/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
06
Macromolecular compounds
[IPC code unknown for A61K 47/61]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
04
Artificial tears; Irrigation solutions
Applicants:
CROMA-PHARMA GMBH [AT/AT]; Industriezeile 15 2100 Leobendorf, AT
Inventors:
PRINZ, Martin; AT
HÖLLER, Sonja; AT
HORNOF, Margit; AT
Agent:
SCHWARZ & PARTNER PATENTANWÄLTE OG; Wipplingerstrasse 30 1010 Wien, AT
NEMEC, Harald; AT
Priority Data:
17169249.403.05.2017EP
Title (EN) STERILE AQUEOUS OPHTHALMIC SOLUTION CONTAINING N-(N-ACETYLCYSTEINYL)-CHITOSAN FOR TREATING NON-INFECTIOUS CORNEAL DISORDERS
(FR) SOLUTION OPHTALMIQUE AQUEUSE STÉRILE CONTENANT DU N-(N-ACÉTYLCYSTÉINYL)-CHITOSANE POUR LE TRAITEMENT DE TROUBLES DE LA CORNÉE NON INFECTIEUX
Abstract:
(EN) The present invention relates to a sterile aqueous ophthalmic solution comprising N-(N-acetylcysteinyl-)chitosan with a content of free thiol groups of from 80 to 280 umol/g polymer, for use in the treatment of a non-infectious corneal disorder, in particular dry eye diseases and persistent corneal epithelial defects, wherein said solution is applied intermittently, characterised by a scheme of treatment wherein the solution is applied to the eye for a period A of 5 days or more, then the application is paused for a period B of at least 2 and at most 180 days and then applied again for a period C of 1 day or more.
(FR) La présente invention concerne une solution ophtalmique aqueuse stérile comprenant du N-(N-acétylcystéinyl-)chitosane ayant une teneur en groupes thiol libres comprise entre 80 et 280 umol/g de polymère, pour une utilisation dans le traitement d'un trouble de la cornée non infectieux, en particulier des maladies des yeux secs et des défauts épithéliaux cornéens persistants, ladite solution étant appliquée par intermittence, caractérisée par une posologie dans laquelle la solution est appliquée à l'œil pendant une période A de 5 jours ou plus, puis l'application est interrompue pendant une période B comprise entre au moins 2 jours et au plus 180 jours, puis la solution est appliquée à nouveau pendant une période C de 1 jour ou plus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)