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1. (WO2018202739) DEVICE AND METHOD FOR MEASURING DIFFUSION OF A COMPOUND ACROSS A MEMBRANE

Pub. No.:    WO/2018/202739    International Application No.:    PCT/EP2018/061268
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Fri May 04 01:59:59 CEST 2018
IPC: G01N 33/50
B01L 3/00
G01N 21/75
Applicants: GALDERMA RESEARCH & DEVELOPMENT
Inventors: ATRUX-TALLAU, Nicolas
Title: DEVICE AND METHOD FOR MEASURING DIFFUSION OF A COMPOUND ACROSS A MEMBRANE
Abstract:
Device (10) for measuring diffusion of a compound across a test membrane (40) comprises a donor assembly (20) comprising a donor plate (22) having at least one through hole (23) and a receptor assembly (30) comprising a receptor plate (32) having at least one receptor well (32a) configured for containing a receiving liquid, said receptor well mirroring the through hole (23), said donor plate (22) being located over the receptor plate (32) and configured to move along a vertical direction (Z) towards the receptor plate (32). The donor assembly (20) comprises a donor chamber (24) mounted in said through hole (23) and extending on both side of the donor plate (22), said donor chamber (24) delimiting an inner cavity (24b) forming a donor well for receiving said compound to be tested and having a lower end (24c) configured to come into contact with said test membrane.