Search International and National Patent Collections

1. (WO2018202723) PREDICTIVE RESPONSE BIOMARKERS TO CORTICOSTEROIDS

Pub. No.:    WO/2018/202723    International Application No.:    PCT/EP2018/061219
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Thu May 03 01:59:59 CEST 2018
IPC: C12Q 1/68
Applicants: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL
CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED
Inventors: DOMÈNECH MORRAL, Eugeni
MANYÉ ALMERO, Josep
LORÉN MORENO, Violeta
ENRIQUE NAVES, Juan
Title: PREDICTIVE RESPONSE BIOMARKERS TO CORTICOSTEROIDS
Abstract:
Predictive response biomarkers to corticosteroids The present invention provides a method for predicting subject's responsiveness to a corticosteroid medical regimen, prior to the start of the medical regimen, the method comprising the step of determining the amount of miR218-5p in an isolated test sample of the subject, wherein if no miR218- p amount is present in the sample, it is indicative that the subject will be responder to the medical regimen, and if miR218-5p is detected in the test sample it is indicative that the subject will not respond to the medical regimen. The invention also provides the use of means for determining the amount of mi R218-5p for predicting subject's responsiveness to a corticosteroid medical regimen.