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1. WO2018202689 - PREPARATION OF 2-([1,2,3]TRIAZOL-2-YL)-BENZOIC ACID DERIVATIVES

Publication Number WO/2018/202689
Publication Date 08.11.2018
International Application No. PCT/EP2018/061172
International Filing Date 02.05.2018
IPC
C07D 249/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
06with aryl radicals directly attached to ring atoms
CPC
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07D 249/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
06with aryl radicals directly attached to ring atoms
Applicants
  • IDORSIA PHARMACEUTICALS LTD [CH]/[CH]
Inventors
  • DÖRRWÄCHTER, Patric
  • SCHMIDT, Gunther
Agents
  • VELKER, Jörg
Priority Data
PCT/EP2017/06045103.05.2017EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PREPARATION OF 2-([1,2,3]TRIAZOL-2-YL)-BENZOIC ACID DERIVATIVES
(FR) PRÉPARATION DE DÉRIVÉS DE L'ACIDE 2-([1,2,3]TRIAZOL-2-YL)-BENZOÏQUE
Abstract
(EN) The present invention relates to a process for the preparation of particular 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (I), to certain crystalline forms of potassium salts of said 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (IK), to certain crystalline forms of said 2-(2H-[1,2,3]triazol-2-yl)-benzoic acid derivatives of formula (I), and to their use in the preparation of pharmaceuticals such as (S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)-(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone.
(FR) La présente invention concerne un procédé de préparation de dérivés particuliers d'acide 2-(2H-[1,2,3]triazol-2-yl)-benzoïque de formule (I), à certaines formes cristallines de sels de potassium desdits dérivés d'acide 2-(2H-[1,2,3]triazol-2-yl)-benzoïque de formule (IK), à certaines formes cristallines desdits dérivés d'acide 2-(2H-[1,2,3]triazol-2-yl)-benzoïque de formule (I), et leur utilisation dans la préparation de produits pharmaceutiques tels que (S)-(2-(5-chloro-4-méthyl-1H-benzo[d]imidazol-2-yl)-2-méthylpyrrolidin-1-yl)-(5-méthoxy-2-(2H-1,2,3-triazol-2-yl)phényl)méthanone.
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