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1. (WO2018202671) IN-BODY PERFUSION SYSTEM

Pub. No.:    WO/2018/202671    International Application No.:    PCT/EP2018/061127
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Thu May 03 01:59:59 CEST 2018
IPC: A61F 2/02
A61M 1/34
A61M 1/36
A61M 5/172
C12N 5/071
Applicants: ANDRETTA, Carlo
Inventors: ANDRETTA, Carlo
Title: IN-BODY PERFUSION SYSTEM
Abstract:
An implantable perfusion device (2) comprises a tubular transmission line (4) with an inlet end (6), an outlet end (8) and a flow restriction element (10) located therebetween, whereby an inlet section (12) of the transmission line is defined between the inlet end and the flow restriction element and whereby an outlet section (14) of the transmission line is defined between the flow restriction element and the outlet end. Moreover, the device comprises a perfusion chamber (16) containing a load of biologically active cells and is provided with a fluid entrance (18), a fluid exit (20) and a chamber volume (22) formed therebetween. The fluid entrance comprises at least one first microchannel platelet (24) and the fluid exit comprises at least one second microchannel platelet (26), each one of the microchannel platelets comprising at least one array of microchannels (28) defining a fluid passage between respective external and internal platelet faces, the microchannels having an opening of 0.2 to 10 μm. The fluid entrance (18) of the perfusion chamber is in fluid communication with the inlet section (12) of the transmission line; and the flow restriction element (10) is configured to establish a predetermined pressure excess in the inlet section (12) versus the outlet section (14).