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1. (WO2018202648) GENERATION OF ACCURATE HYBRID DATASETS FOR QUANTITATIVE MOLECULAR IMAGING

Pub. No.:    WO/2018/202648    International Application No.:    PCT/EP2018/061083
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed May 02 01:59:59 CEST 2018
IPC: G06T 11/00
Applicants: KONINKLIJKE PHILIPS N.V.
Inventors: BAI, Chuanyong
ANDREYEV, Andriy
SONG, Xiyun
YE, Jinghan
ZHANG, Bin
DWIVEDI, Shekhar
MAO, Yanfei
HU, Zhiqiang
Title: GENERATION OF ACCURATE HYBRID DATASETS FOR QUANTITATIVE MOLECULAR IMAGING
Abstract:
A non-transitory computer readable medium storing instructions readable and executable by an imaging workstation (14) including at least one electronic processor (16) to perform a dataset generation method (100) operating on emission imaging data acquired of a patient for one or more axial frames at a corresponding one or more bed positions, the method comprising: (a) identifying a frame of interest from the one or more axial frames; (b) generating simulated lesion data by simulating emission imaging data for the frame of interest of at least one simulated lesion placed in the frame of interest; (c) generating simulated frame emission imaging data by simulating emission imaging data for the frame of interest of the patient; (d) determining a normalization factor comprising a ratio of the value of a quantitative metric for the simulated patient data and the value of the quantitative metric for the emission imaging data acquired of the same patient for the frame of interest; and (e) generating a hybrid data set comprising the emission imaging data acquired of the patient for the one or more axial frames at the corresponding one or more bed positions with the frame of interest replaced by a combination of the simulated lesion data scaled by the normalization factor and the emission imaging data acquired of the patient for the frame of interest.