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1. (WO2018202537) PROCESS FOR THE PREPARATION OF AN AZOLIC DERIVATIVE

Pub. No.:    WO/2018/202537    International Application No.:    PCT/EP2018/060713
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Fri Apr 27 01:59:59 CEST 2018
IPC: C07D 401/06
Applicants: SEEGPHARM SA
Inventors: CASTALDI, Graziano
BARATELLA, Marco
GABOARDI, Mauro
BARUTO, Alessandro
Title: PROCESS FOR THE PREPARATION OF AN AZOLIC DERIVATIVE
Abstract:
The present invention refers to a process for the preparation of an azolic derivative used in the treatment of onychomycosis. Said process comprises the reaction between (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane and 4-methylenepiperidine or a salt thereof, in the presence of a zinc derivative in an alcoholic solvent.