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1. (WO2018202471) TMEM16A MODULATION FOR DIAGNOSTIC OR THERAPEUTIC USE IN PULMONARY HYPERTENSION (PH)

Pub. No.:    WO/2018/202471    International Application No.:    PCT/EP2018/060415
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Wed Apr 25 01:59:59 CEST 2018
IPC: A61K 39/395
A61K 45/06
A61K 31/4375
G01N 33/50
Applicants: BAYER AKTIENGESELLSCHAFT
Inventors: OLSCHEWSKI, Andrea
NAGY, Bence
NAGARAJ, Chandran
PAPP, Rita
Title: TMEM16A MODULATION FOR DIAGNOSTIC OR THERAPEUTIC USE IN PULMONARY HYPERTENSION (PH)
Abstract:
Provided is a method of assessing the occurrence or the risk of occurrence of pulmonary hypertension (PH), in which an increased level of expression of the channel TMEM16A indicates a risk of occurrence of PH. Provided is also a method of treating PH, in which a compound effective in reducing activity of TMEM16A is being administered. Provided are also screening methods for a compound suitable for modulating activity ex vivo and in vitro and for PH treatment in vivo.