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1. (WO2018202224) FILM-COATED TABLETS OF DEFERASIROX
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Pub. No.: WO/2018/202224 International Application No.: PCT/CZ2018/000017
Publication Date: 08.11.2018 International Filing Date: 03.05.2018
IPC:
A61K 9/20 (2006.01) ,A61K 9/28 (2006.01) ,A61K 31/4196 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
Applicants:
ZENTIVA, K.S. [CZ/CZ]; U Kabelovny 130 102 37 Praha 10, CZ
Inventors:
GAJDOSOVA, Michaela; SK
SVOBODOVA, Jaroslava; CZ
PECEK, Daniel; CZ
Agent:
JIROTKOVA, Ivana; Rott, Ruzicka & Guttmann Vinohradska 37 120 00 Praha 2, CZ
Priority Data:
PV 2017-25504.05.2017CZ
Title (EN) FILM-COATED TABLETS OF DEFERASIROX
(FR) COMPRIMÉS PELLICULÉS DE DÉFÉRASIROX
Abstract:
(EN) The solution relates to a pharmaceutical composition in the form of a film-coated tablet, characterized in that it comprises the active ingredient Deferasirox of formula (I), or its pharmaceutically acceptable salt, in an amount of 40% by weight or less, preferably 40% by weight, based on the total weight of the tablet core, and at least one pharmaceutically acceptable excipient. Another solution provides a process for producing film-coated tablets, containing Deferasirox as the active ingredient. Deferasirox exhibits a chelating effect on iron ions, which makes it useful for the treatment of chronic iron overload of the organism due to frequent blood transfusions.
(FR) La solution concerne une composition pharmaceutique se présentant sous la forme d'un comprimé pelliculé, caractérisé en ce qu'il comprend le principe actif déférasirox de formule (I), ou son sel pharmaceutiquement acceptable, en une quantité de 40 % en poids ou moins, de préférence 40 % en poids, sur la base du poids total du noyau de comprimé, et au moins un excipient pharmaceutiquement acceptable. Une autre solution concerne un procédé de production des comprimés pelliculés contenant du déférasirox en tant que principe actif. Le déférasirox présente un effet chélateur des ions fer, ce qui le rend utilisable pour le traitement d'une surcharge en fer chronique de l'organisme due à des transfusions sanguines fréquentes. (Formule (I))
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)