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1. (WO2018202039) HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/202039 International Application No.: PCT/CN2018/085330
Publication Date: 08.11.2018 International Filing Date: 02.05.2018
IPC:
C07D 495/04 (2006.01) ,C07D 487/04 (2006.01) ,A61K 31/4353 (2006.01) ,A61P 9/12 (2006.01) ,A61P 19/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
06
Antigout agents, e.g. antihyperuricemic or uricosuric agents
Applicants:
成都海创药业有限公司 HINOVA PHARMACEUTICALS INC. [CN/CN]; 中国四川省成都市 高新区科园南路5号蓉药大厦A栋4层1号 No. 1, 4rd Floor, RongYao Building A 5 Keyuan South Road, High-Tech Zone Chengdu, Sichuan 610041, CN
Inventors:
樊磊 FAN, Lei; CN
杜武 DU, Wu; CN
胥珂馨 XU, Kexin; CN
陈锞 CHEN, Ke; CN
王飞 WANG, Fei; CN
吴孝全 WU, Xiaoquan; CN
罗童川 LUO, Tongchuan; CN
张少华 ZHANG, Shaohua; CN
李兴海 LI, Xinghai; CN
陈元伟 CHEN, Yuanwei; CN
Agent:
成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP); 中国四川省成都市 高新区衣冠庙邮局A-42号信箱 The Yiguanmiao Post Office Box A-42, Hi-Tech Zone Chengdu, Sichuan 610041, CN
Priority Data:
201710305385.603.05.2017CN
Title (EN) HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR
(FR) COMPOSÉ HÉTÉROCYCLIQUE ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 杂环化合物及其制备方法
Abstract:
(EN) Disclosed in the present invention is a compound as represented by formula (A), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof. The new compound as represented by formula (A) disclosed in the present invention exhibits good URAT1 inhibitory activities, providing a new medicinal possibility for the clinical treatment of diseases associated with abnormal URAT1 activities.
(FR) La présente invention concerne un composé tel que représenté par la formule (A), ou un stéréoisomère de celui-ci, ou son sel pharmaceutiquement acceptable, ou un solvate dudit composé. Le nouveau composé représenté par la formule (A) de la présente invention a de bonnes activités inhibitrices de l'URAT1, fournissant ainsi une nouvelle possibilité médicinale pour le traitement clinique de maladies associées à des activités anormales d'URAT1.
(ZH) 本发明公开了式(A)所示的化合物、或其立体异构体、或其药学上可接受的盐、或其溶剂合物,本发明公开的式(A)所示的新化合物,表现出了良好的URAT1抑制活性,为临床治疗与URAT1活性异常相关的疾病提供了一种新的药用可能。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)