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1. (WO2018201794) CHIMERIC ANTIGEN RECEPTOR AGAINST HUMAN CD19 ANTIGEN AND APPLICATION THEREOF

Pub. No.:    WO/2018/201794    International Application No.:    PCT/CN2018/078450
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Fri Mar 09 00:59:59 CET 2018
IPC: C07K 19/00
C12N 15/867
C12N 15/66
C12N 5/10
A61K 35/17
A61P 35/00
A61P 35/02
Applicants: CHONGQING PRECISION BIOTECH COMPANY LIMITED
重庆精准生物技术有限公司
Inventors: ZHANG, Wei
张巍
Title: CHIMERIC ANTIGEN RECEPTOR AGAINST HUMAN CD19 ANTIGEN AND APPLICATION THEREOF
Abstract:
Provided is a chimeric antigen receptor (CAR) against human CD19 antigen, consisting of a single-chain antibody (scFv) recognizing human CD19 antigen, a hinge region, a transmembrane region, and an intracellular signaling domain connected in sequence. The single-chain antibody (scFv) recognizing human CD19 antigen has an amino acid sequence as shown in SEQ ID NOs. 1, 2, 3, 4, 35, 36, or 37. The CAR is expressed in an immune cell, can eliminate a tumor cell, and can be used in a targeted therapy for a tumor.