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1. (WO2018201543) COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF
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Pub. No.: WO/2018/201543 International Application No.: PCT/CN2017/086243
Publication Date: 08.11.2018 International Filing Date: 27.05.2017
IPC:
C07D 493/22 (2006.01) ,C07D 493/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
22
in which the condensed system contains four or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
重庆泰濠制药有限公司 CHONGQING TAIHAO PHARMACEUTICAL CO., LTD. [CN/CN]; 中国重庆市 九龙坡区二郎创业路105号C-3 C-3 No. 105, Chuangye Road, Erlang, Jiulongpo District Chongqing 400039, CN
重庆惠源医药有限公司 ATHENEX PHARMACEUTICALS (CHONGQING) LIMITED [CN/CN]; 中国重庆市 巴南区麻柳沿江开发区科技孵化楼 Building of Science&Technology Incubation of Chongqing Maliu Riverside Development Zone Chongqing 400039, CN
Inventors:
张宪恕 ZHANG, Xianshu; CN
芬尼⋅纳撒尼尔 FINNEY, Nathaniel; CN
郑保富 ZHENG, Baofu; CN
Agent:
北京集佳知识产权代理有限公司 UNITALEN ATTORNEYS AT LAW; 中国北京市 朝阳区建国门外大街22号赛特广场7层 7th Floor, Scitech Place No. 22, Jian Guo Men Wai Ave., Chao Yang District Beijing 100004, CN
Priority Data:
201710315199.005.05.2017CN
Title (EN) COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF
(FR) COMPOSÉ, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 一种化合物及其制备方法和应用
Abstract:
(EN) An intermediate for preparing eribulin and a preparation method and application thereof are provided. The preparation method of eribulin comprises causing an intramolecular coupling reaction of the alkenyl iodide with the aldehyde group in the intermediate molecule to generate a key intermediate, followed by a desulfonylation reaction.
(FR) L'invention concerne un intermédiaire pour la préparation d'éribuline, son procédé de préparation et son application. Le procédé de préparation d'éribuline de l'invention consiste à provoquer une réaction de couplage intramoléculaire de l'iodure d'alcényle avec le groupe aldéhyde dans la molécule intermédiaire afin de générer un intermédiaire clé, suivie d'une réaction de désulfonylation.
(ZH) 提供一种用于制备艾日布林的中间体及其制备方法与应用。艾日布林的制备方法包括将中间体分子中的烯基碘与醛基发生分子内耦合反应生成关键中间体,然后再进行脱磺酰基反应。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)