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1. (WO2018201260) BIOCOMPATIBLE HYDROGEL COMPOSITIONS AND USES THEREOF

Pub. No.:    WO/2018/201260    International Application No.:    PCT/CA2018/050537
Publication Date: Fri Nov 09 00:59:59 CET 2018 International Filing Date: Sat May 05 01:59:59 CEST 2018
IPC: A61L 27/52
A61L 27/20
A61L 27/24
A61K 31/726
A61K 38/39
A61K 47/55
C07K 14/78
Applicants: OTTAWA HEART INSTITUTE RESEARCH CORPORATION
Inventors: RUEL, Marc
SUURONEN, Erik
ALARCON, Emilio
Title: BIOCOMPATIBLE HYDROGEL COMPOSITIONS AND USES THEREOF
Abstract:
Provided herein are biocompatible and/or biodegradable hydrogel compositions comprising native collagen and chondroitin sulfate, the collagen and chondroitin sulfate being chemically cross-linked thereby forming a matrix. The native collagen may comprise recombinant human collagen type I (rHCI), recombinant human collagen type III (rHCIII), or a combination thereof, for example. Methods and uses thereof for regeneration or repair of tissue, improvement of tissue function, mechanical stabilization of tissue, prevention of tissue damage, or prevention of tissue loss of function are described, particularly with respect to cardiac tissue and myocardial infarction events.