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1. (WO2018201167) PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/201167    International Application No.:    PCT/US2018/039289
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue Jun 26 01:59:59 CEST 2018
IPC: C07D 213/75
Applicants: AVIARA PHARMACEUTICALS, INC.
Inventors: BIEDIGER, Ronald, J.
BENISH, Michele, A.
HARDY, Lindsay, Bonner
BOYD, Vincent, A.
MARKET, Robert, V.
THRASH, Thomas, P.
YOUNG, Brandon, M.
Title: PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF
Abstract:
Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.