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|1. (WO2018201146) COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION|
|Applicants:||CASE WESTERN RESERVE UNIVERSITY
UNIVERSITY OF PITTSBURGH
|Title:||COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION|
This application relates to compounds and methods of treating retinal degeneration associated with inherited rhodopsin mutations in the ocular tissue of a subject. The retinal degeneration, can include, for example, macular degeneration, including age-related macular degeneration, Stargardt disease, and retinitis pigmentosa. The retinitis pigmentosa can include autosomal dominate retinitis pigmentosa associated with a P23H RHO mutation. A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I), wherein the compound of formula (I) acts as a chaperone of rhodopsin.