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1. (WO2018201137) SELECTIVE AGONIST OF α6 CONTAINING nAChRs
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Pub. No.: WO/2018/201137 International Application No.: PCT/US2018/030207
Publication Date: 01.11.2018 International Filing Date: 30.04.2018
IPC:
A61K 31/4995 (2006.01) ,A61P 25/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4995
Pyrazines or piperazines forming part of bridged ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
WAHLBERG, Lars, Ulrik [SE/US]; US (US)
SANIONA A/S [DK/DK]; Baltorpvej 154 DK-2750 Ballerup, DK (AllExceptUS)
Inventors:
WAHLBERG, Lars, Ulrik; US
DYHRING, Tino; DK
PETERS, Dan; DK
CHRISTOPHERSEN, Palle; DK
NIELSEN, Karin, Sandager; DK
WAHLBERG, Lars Ulrik; US
AMRUTKAR, Dipak; DK
Agent:
LODISE, Stephanie, A.; US
Priority Data:
15/964,77127.04.2018US
17168636.328.04.2017EP
Title (EN) SELECTIVE AGONIST OF α6 CONTAINING nAChRs
(FR) AGONISTE SÉLECTIF DES NACHR À SOUS-UNITÉ α6
Abstract:
(EN) The present invention relates to a subtype selective partial agonist of a6 containing nicotinic acetylcholine receptors. Due to its uniquely selective and functional profile, 9- methyl-3-pyridin-3-yl-3,9-diaza-bicyclo [3.3.1] nonane may be useful in the treatment, prevention and/or alleviation of a disease, disorder and/or condition which is responsive to activation of a nicotinic acetylcholine receptor (nAChR) in a subject, wherein the nAChR comprises at least one cholinergic receptor nicotinic alpha 6 subunit (nAChRa6). Preferably, said disease, disorder and/or condition is a Parkinsonian disorder or pain.
(FR) La présente invention concerne un agoniste partiel sélectif de sous-type des récepteurs nicotiniques de l'acétylcholine à sous-unité α6. Du fait de son profil fonctionnel et sélectif unique, le 9-méthyl-3-pyridine-3-yl-3,9-diaza-bicyclo [3.3.1] nonane peut être utilisable chez un patient dans le traitement, la prévention et/ou le soulagement d'une maladie, d'un trouble et/ou d'un état pathologique susceptible de répondre à l'activation d'un récepteur nicotinique de l'acétylcholine (nAChR, pour "nicotinic acetylcholine receptor"), le nAChR comprenant au moins une sous-unité alpha 6 nicotinique du récepteur cholinergique (nAChRα6). De préférence, ladite maladie, trouble et/ou état pathologique est un trouble ou une douleur lié(s) à la maladie de Parkinson.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)