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1. (WO2018201131) FORMULATIONS, METHODS, KITS, AND DOSAGE FORMS FOR TREATING ATOPIC DERMATITIS AND FOR IMPROVED STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT

Pub. No.:    WO/2018/201131    International Application No.:    PCT/US2018/030158
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue May 01 01:59:59 CEST 2018
IPC: A61K 31/519
A61P 37/00
C07D 487/04
Applicants: ASANA BIOSCIENCES, LLC
Inventors: RAILKAR, Aruna
JARIWALA, Paras
PHUAPRADIT, Wantanee
ZAMMIT, David
DENIS, Louis
RAO, Niranjan
USANSKY, Helen
GUPTA, Sandeep
Title: FORMULATIONS, METHODS, KITS, AND DOSAGE FORMS FOR TREATING ATOPIC DERMATITIS AND FOR IMPROVED STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT
Abstract:
Embodiments of the disclosure relate generally to formulations, methods of treatment, kits, and dosage forms for treating inflammatory disorders, including atopic dermatitis, or cancer, the formulations comprising an active pharmaceutical ingredient. The formulation provided comprises granules, wherein the granules comprise: micronized active ingredient; one or more granulation binders; one or more fillers; one or more disintegrants; and one or more antioxidants. In one embodiment, the methods of treatment include orally administering the active ingredient to a subject suffering from atopic dermatitis, where the active ingredient is in an amount of about 20 mg to about 80 mg.