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1. (WO2018201099) EPSTEIN-BARR VIRUS ANTIBODIES AND USES THEREOF
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Pub. No.: WO/2018/201099 International Application No.: PCT/US2018/030030
Publication Date: 01.11.2018 International Filing Date: 27.04.2018
IPC:
A61K 39/245 (2006.01) ,A61K 39/395 (2006.01) ,C07K 14/05 (2006.01) ,C07K 16/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
245
Herpetoviridae, e.g. herpes simplex virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
Applicants:
CITY OF HOPE [US/US]; 1500 East Duarte Road Duarte, California 91010-3000, US
CALIFORNIA INSTITUTE OF TECHNOLOGY [US/US]; 1200 E. California Blvd. Pasadena, California 91125, US
Inventors:
OGEMBO, Javier Gordon; US
MUTSVUNGUMA, Lorraine Zvichapera; US
ONDRUS, Alison Evelynn; US
Agent:
WANG, Yingli; US
Priority Data:
62/491,94528.04.2017US
Title (EN) EPSTEIN-BARR VIRUS ANTIBODIES AND USES THEREOF
(FR) ANTICORPS CONTRE LE VIRUS D’EPSTEIN-BARR ET UTILISATIONS DE CEUX-CI
Abstract:
(EN) Disclosed herein are antibodies or immunogenic fragments thereof that specifically bind to Epstein-Barr virus (EBV) glycoprotein 350 (gp350) or 220 or one or more epitopes of EBV gp350 and neutralize EBV infection. Also disclosed are immunogenic peptides comprising one or more gp350 epitopes, EBV antibody-small molecule conjugates and pharmaceutical compositions comprising the antibody or an immunogenic fragment thereof, one or more epitopes of EBV gp350, one or more immunogenic peptides, or the EBV antibody-small molecule conjugate. The antibodies, epitopes, immunogenic peptides, conjugates, and pharmaceutical compositions can be used to treat or prevent EBV infections and EBV-associated conditions and diseases.
(FR) La présente invention concerne des anticorps ou des fragments immunogènes de ceux-ci qui se lient spécifiquement à la glycoprotéine 350 (gp350) ou 220 du virus d’Epstein-Barr (EBV) ou un ou plusieurs épitopes de gp350 d’EBV et neutralisent une infection par EBV. L’invention concerne en outre des peptides immunogènes comprenant un ou plusieurs épitopes de gp350, des conjugués anticorps contre EBV-petite molécule et des compositions pharmaceutiques comprenant l’anticorps ou un fragment immunogène de celui-ci, un ou plusieurs épitopes de gp350 d’EBV, un ou plusieurs peptides immunogènes, ou le conjugué anticorps contre EBV-petite molécule. Les anticorps, les épitopes, les peptides immunogènes, les conjugués et les compositions pharmaceutiques peuvent être utilisés pour traiter ou prévenir des infections par EBV et des affections et maladies associées à EBV.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)