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1. (WO2018201090) SYNTHESIS OF SPHERICAL NUCLEIC ACIDS USING LIPOPHILIC MOIETIES

Pub. No.:    WO/2018/201090    International Application No.:    PCT/US2018/030021
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 28 01:59:59 CEST 2018
IPC: A61K 31/7084
A61K 47/50
A61K 9/127
A61K 9/51
C12N 15/00
Applicants: EXICURE, INC.
Inventors: KANG, Richard
NALLAGATLA, Subbarao
ANDERSON, Bart
KANDIMALLA, Ekambar
Title: SYNTHESIS OF SPHERICAL NUCLEIC ACIDS USING LIPOPHILIC MOIETIES
Abstract:
Spherical nucleic acids (SNA) carrying self-aggregating oligonucleotides are described herein. Compositions of the SNA include discrete nanostructures that are not aggregated. Related methods are also described.