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1. (WO2018201069) TARGETING NANOPARTICLES

Pub. No.:    WO/2018/201069    International Application No.:    PCT/US2018/029991
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 28 01:59:59 CEST 2018
IPC: A61K 49/00
A61K 49/04
A61K 51/00
Applicants: TEXAS CHILDREN'S HOSPITAL
TEXAS HEART INSTITUTE
Inventors: WOODSIDE, Darren
VANDERSLICE, Peter
MARKET, Robert
BIEDIGER, Ronald
DIXON, Richard
WILLERSON, James T.
ANNAPRAGADA, Ananth
TANIFUM, Eric
Title: TARGETING NANOPARTICLES
Abstract:
Disclosed herein is a composition comprising a plurality of liposomes having an average diameter of less than 400 nanometers, wherein the plurality of liposomes comprise: a first lipid or phospholipid; a second lipid or phospholipid which is derivatized with a polymer; and a sterically bulky excipient capable of stabilizing the liposomes; a third lipid or phospholipid derivatized with a polymer terminated with an integrin targeting component; DSPE or a fourth lipid or phospholipid derivatized with a group binding a contrast enhancing agent wherein the plurality of liposomes optionally encapsulates a payload component consisting of one or more bioactive agents.