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1. (WO2018201056) CELLS EXPRESSING A BCMA-TARGETING CHIMERIC ANTIGEN RECEPTOR, AND COMBINATION THERAPY WITH A GAMMA SECRETASE INHIBITOR

Pub. No.:    WO/2018/201056    International Application No.:    PCT/US2018/029963
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 28 01:59:59 CEST 2018
IPC: A61K 38/17
A61K 35/17
C07K 14/725
C07K 16/28
C12N 5/0783
Applicants: NOVARTIS AG
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors: DALEY, Michael
GRANDA, Brian
MILONE, Michale, C.
NUNEZ CRUZ, Selene, Guadalupe
Title: CELLS EXPRESSING A BCMA-TARGETING CHIMERIC ANTIGEN RECEPTOR, AND COMBINATION THERAPY WITH A GAMMA SECRETASE INHIBITOR
Abstract:
The invention relates to the treatment of diseases associated with expression of BCMA, in particular myelomas. The invention relates to combination therapies of a BCMA CAR-expressing cell and a gamma secretase inhibitor.