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1. (WO2018201022) COMPOSITIONS AND METHODS FOR VACCINE DELIVERY
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Pub. No.: WO/2018/201022 International Application No.: PCT/US2018/029906
Publication Date: 01.11.2018 International Filing Date: 27.04.2018
IPC:
A61K 9/127 (2006.01) ,A61K 39/015 (2006.01) ,C07K 14/445 (2006.01) ,C12N 15/30 (2006.01) ,A61K 39/39 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
002
Protozoa antigens
015
Hemosporidia antigens, e.g. Plasmodium antigens
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
44
from protozoa
445
Plasmodium
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
30
Genes encoding protozoal proteins, e.g. from Plasmodium, Trypanosoma, Eimeria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
Applicants:
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. [US/US]; 6720-A Rockledge Drive, Suite 100 Bethesda, Maryland 20817, US
Inventors:
DUTTA, Sheetij; US
BECK, Zoltan; US
ALVING, Carl; US
MATYAS, Gary; US
Agent:
GROTE, Eric; US
SMYTH, Robert J.; US
LEE, Janice H.; US
LOWEN, Gregory T.; US
Priority Data:
62/491,46328.04.2017US
Title (EN) COMPOSITIONS AND METHODS FOR VACCINE DELIVERY
(FR) COMPOSITIONS ET MÉTHODES D'ADMINISTRATION DE VACCINS
Abstract:
(EN) The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23°C, and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.
(FR) L'invention concerne des compositions pharmaceutiques comprenant au moins un antigène et une composition d'adjuvant, la composition d'adjuvant comprenant une saponine et un liposome. Le liposome de la composition comprend du monophosphoryl lipide A (MPLA), du cholestérol et un phospholipide qui est à l'état cristallin liquide à une température supérieure ou égale à 23 °C, et la concentration en cholestérol par rapport au lipide dans le liposome est supérieure à 50 % (mol/mol). L'antigène présent dans la composition est une protéine circumsporozoïte recombinante (rCSP) de Plasmodium falciparum soluble comprenant la séquence d'acides aminés de SEQ ID No : 1, ou un peptide rCSP de P. falciparum qui est identique à au moins 95 % à la séquence d'acides aminés de SEQ ID No : 1.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)