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1. (WO2018201017) DENDRITIC CELL TARGETED ADENOVIRUS FOR VACCINATION
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Pub. No.: WO/2018/201017 International Application No.: PCT/US2018/029900
Publication Date: 01.11.2018 International Filing Date: 27.04.2018
IPC:
A61P 35/00 (2006.01) ,A61P 37/04 (2006.01) ,A61K 47/68 ,C12N 15/861 (2006.01) ,C07K 16/28 (2006.01) ,C12N 15/40 (2006.01) ,C12N 15/63 (2006.01) ,A61K 35/761 (2015.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
[IPC code unknown for A61K 47/68]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
861
Adenoviral vectors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
31
Genes encoding microbial proteins, e.g. enterotoxins
33
Genes encoding viral proteins
40
Proteins from RNA viruses, e.g. flaviviruses
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
[IPC code unknown for A61K 35/761]
Applicants:
WASHINGTON UNIVERSITY [US/US]; One Brookings Drive Saint Louis, Missouri 63130, US
PRECISION VIROLOGICS, INC. [US/US]; Suite 304 4320 Forest Park Ave Saint Louis, Missouri 63108, US
Inventors:
CURIEL, David; US
KATZMAN, Daniel; AR
DMITRIEV, Igor; US
Agent:
ZACKSON, Saul; US
Priority Data:
62/490,76427.04.2017US
Title (EN) DENDRITIC CELL TARGETED ADENOVIRUS FOR VACCINATION
(FR) ADÉNOVIRUS CIBLANT DES CELLULES DENDRITIQUES POUR LA VACCINATION
Abstract:
(EN) Disclosed are camelid single domain antibody (sdAb) against dendritic cell surface antigens such as Clec9A and CD40. Also disclosed are chimeric adenoviruses which can be used as vaccines against a pathogen or cancer. A chimeric adenovirus targeted to dendritic cells incorporates a sequence encoding an sdAb against a dendritic cell surface antigen. A chimeric adenovirus includes a phage T4 fibritin trimerization foldon to replace the Ad5 fiber knob. Furthermore, the E1A/B genetic region of a chimeric adenovirus can be replaced with a heterologous sequence such as a structural gene from a heterologous virus or a sequence encoding a tumor antigen. Examples of heterologous viruses include flaviviruses such as Zika, Chikungunya, Dengue, yellow fever, and West Nile virus. Exemplary Zika sequences introduced into a chimeric adenovirus include full length prM, and the E ectodomain.
(FR) L'invention concerne un anticorps à domaine unique de camélidé (sdAb) contre des antigènes de surface de cellules dendritiques tels que Clec9A et CD40. L'invention concerne également des adénovirus chimériques qui peuvent être utilisés en tant que vaccins contre un pathogène ou un cancer. Un adénovirus chimérique ciblé sur des cellules dendritiques comprend une séquence codant pour un sdAb contre un antigène de surface de cellule dendritique. Un adénovirus chimérique comprend un foldon de trimérisation de fibritine du phage T4 pour remplacer le bouton de fibre Ad5. En outre, la région génétique E1A/B d'un adénovirus chimérique peut être remplacée par une séquence hétérologue telle qu'un gène structural provenant d'un virus hétérologue ou d'une séquence codant pour un antigène tumoral. Des exemples de virus hétérologues comprennent des flavivirus tels que le Zika, le Chikungunya, la Dengue, la fièvre jaune et le virus du Nil occidental. Des exemples de séquences Zika introduites dans un adénovirus chimérique comprennent la prM pleine longueur et l'ectodomaine E.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)