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1. (WO2018200931) COMPOSITIONS AND METHODS FOR TREATING CANCER

Pub. No.:    WO/2018/200931    International Application No.:    PCT/US2018/029747
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 28 01:59:59 CEST 2018
IPC: A61P 35/02
A61K 31/16
C07C 233/18
Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
UNIVERSITAT DE BARCELONA
LOUGHRAN, JR., Thomas P.
FABRIAS, Gemma
ABAD, Jose Luis
CASAS, Josefina
Inventors: LOUGHRAN, JR., Thomas P.
FABRIAS, Gemma
ABAD, Jose Luis
CASAS, Josefina
FEITH, David J.
TAN, Su-Fern
PEARSON, Jennifer M.
CIRILO, Antonio Delgado
Title: COMPOSITIONS AND METHODS FOR TREATING CANCER
Abstract:
The present application provides novel compositions and methods for treating acute myeloid leukemia (AML). Compounds of the invention are acid ceramidase inhibitors, reduce AML cell viability, inhibit AML cell proliferation, increase cell death of AML cells, and induce apoptosis in AML cells. A primary compound of the invention is SACLAC: 2-chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide. The bromine analog of SACLAC (SABRAC: 2-bromo-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide) is also useful for treating AML. SACLAC has much better activity than other know drugs used to treat AML.