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1. (WO2018200918) FORMULATIONS OF HUMAN ANTI-RANKL ANTIBODIES, AND METHODS OF USING THE SAME

Pub. No.:    WO/2018/200918    International Application No.:    PCT/US2018/029728
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Sat Apr 28 01:59:59 CEST 2018
IPC: A61K 39/395
C07K 16/28
Applicants: AMGEN INC.
Inventors: BRYCH, Stephen, Robert
WONG, Lyanne, M.
FALLON, Jaymille
GOSS, Monica, Michelle
GU, Jian, Hua
GHATTYVENKATAKRISHNA, Pavan, K.
Title: FORMULATIONS OF HUMAN ANTI-RANKL ANTIBODIES, AND METHODS OF USING THE SAME
Abstract:
Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.