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|1. (WO2018200855) NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING|
|Applicants:||THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
|Inventors:||YU, Paul, B.
SANDERSON, Philip, Edward
|Title:||NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING|
The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).