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1. (WO2018200788) OLIGONUCLEOTIDE BINDING AGENTS
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Pub. No.: WO/2018/200788 International Application No.: PCT/US2018/029533
Publication Date: 01.11.2018 International Filing Date: 26.04.2018
IPC:
C12Q 1/68 (2018.01) ,G01N 33/15 (2006.01) ,A61B 5/055 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
05
Measuring for diagnosis by means of electric currents or magnetic fields
055
involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
Applicants:
BERYLLIUM, LLC [US/US]; 3 Preston Court Bedford, Massachusetts 01730, US
Inventors:
COHEN, Dalia; US
MARKUS, Michelle; US
JIANG, Jun; US
GUIRALDELLI, Michel; US
BOYD, Justin; US
RADETICH, Branko; US
NIRMALA, Nanguneri; US
PONTIN, Johan; US
Agent:
COWLES, Christopher R.; US
CHACLAS, George N.; US
CHOW, Stephen Y.; US
COHEN, Jerry; US
EMMONS, Richard B.; US
FOLEY, Shawn P.; US
GOLDMAN, Gabriel; US
GOMES, David W.; US
HASAN, Shahid; US
JOBSE, Bruce D.; US
LOPEZ, Orlando; US
MARAIA, Joseph M.; US
MCGRATH, Daniel; US
MILLS, Steven M.; US
MOORE, Ronda P.; US
QUINN, Joseph P.; US
SCHEPPER, Marlo M.; US
SERIO, John C.; US
SORKIN, Paul D.; US
SUSAN, Janine M.; US
CLARKE, J.D., PH.D., Daniel W.; US
Priority Data:
62/490,36226.04.2017US
Title (EN) OLIGONUCLEOTIDE BINDING AGENTS
(FR) AGENTS DE LIAISON D'OLIGONUCLÉOTIDES
Abstract:
(EN) The present disclosure relates to development and performance of screening methods capable of efficiently identifying candidate lead compounds that bind regulatory RNA oligonucleotides in a sequence-specific manner and exert a biological effect upon such regulatory molecules. Candidate lead compounds possessing RNA binding sequence specificity and targeted biological activity are described, as are approaches for merging structural, NMR-derived data with biological reporter assay results. Compound validation approaches capable of identifying the site(s) of action of such compounds within targeted RNA oligonucleotides are also provided.
(FR) La présente invention concerne le développement et la performance de procédés de criblage aptes à identifier efficacement des composés de plomb candidats se liant à des oligonucléotides ARN régulateurs d'une manière spécifique à une séquence et à exercer un effet biologique sur de telles molécules régulatrices. Des composés de plomb candidats possédant une spécificité de séquence de liaison à l'ARN et une activité biologique ciblée sont décrits, ainsi que des approches permettant de fusionner des données structurales, dérivées par RMN avec des résultats de dosage de rapporteur biologique. L'invention concerne également des approches de validation de composés aptes à identifier le(s) site(s) d'action de tels composés dans des oligonucléotides ARN ciblés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)