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1. (WO2018200750) 3-DIMENSIONAL (3D) TISSUE-ENGINEERED MUSCLE FOR TISSUE RESTORATION

Pub. No.:    WO/2018/200750    International Application No.:    PCT/US2018/029473
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 26 01:59:59 CEST 2018
IPC: C07K 14/78
Applicants: PURDUE RESEARCH FOUNDATION
Inventors: VOYTIK-HARBIN, Sherry L.
HALUM, Stacey L.
BROOKES, Sarah
ZHANG, Hongji
Title: 3-DIMENSIONAL (3D) TISSUE-ENGINEERED MUSCLE FOR TISSUE RESTORATION
Abstract:
The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.