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1. (WO2018200687) ENZYMATIC CIRCUITS FOR MOLECULAR SENSORS

Pub. No.:    WO/2018/200687    International Application No.:    PCT/US2018/029382
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 26 01:59:59 CEST 2018
IPC: C12Q 1/68
G01N 27/327
G01N 27/414
G01N 33/487
Applicants: ROSWELL BIOTECHNOLOGIES, INC.
Inventors: MERRIMAN, Barry, L.
GOVINDARAJ, Venkatesh, Alagarswamy
MOLA, Paul
GEISER, Tim
Title: ENZYMATIC CIRCUITS FOR MOLECULAR SENSORS
Abstract:
In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.