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1. (WO2018200680) COMPOSITIONS AND METHODS FOR TREATING TRAUMATIC BRAIN INJURY

Pub. No.:    WO/2018/200680    International Application No.:    PCT/US2018/029372
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Thu Apr 26 01:59:59 CEST 2018
IPC: A61K 31/385
A61K 31/4178
A61K 31/661
A61K 31/662
A61K 45/06
A61K 38/06
A61K 9/00
A61P 25/00
A61P 25/28
A61P 43/00
Applicants: ISCHEMIX LLC
Inventors: BAGUISI, Alexander
BEEUWKES, Reinier
CASALE, Ralph
DEWAHL, David, A. Jr.
KATES, Steven, A.
LADER, Alan, S.
Title: COMPOSITIONS AND METHODS FOR TREATING TRAUMATIC BRAIN INJURY
Abstract:
The present invention relates, in certain embodiments, to methods for preventing and/or treating neurodegenerative damage (e.g., secondary cascade of neurodegenerative damage) and improving functional outcomes (e.g., outcomes associated with cognitive, behavior and sensorimotor function) caused by traumatic brain injury using neuroprotective lipoyl compounds. The present invention also provides, in various embodiments, compositions for use in treating and/or preventing TBI in a subject in need thereof, compounds for use in the manufacture of a medicament for treating and/or preventing TBI in a subject in need thereof, and methods of preparing a pharmaceutical composition for treating and/or preventing secondary brain damage caused by TBI.