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1. (WO2018200615) MODIFIED MRI CONTRAST AGENTS AND USES THEREOF
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Pub. No.: WO/2018/200615 International Application No.: PCT/US2018/029271
Publication Date: 01.11.2018 International Filing Date: 25.04.2018
IPC:
A61K 49/10 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 5th Floor Oakland, California 94607, US
VYBYL HOLDINGS, INC. [US/US]; 2501 Davey Road Woodridge, Illinois 60517, US
Inventors:
LEGUYADER, Clare L. M.; US
GIANNESCHI, Nathan C.; US
CALLMANN, Cassandra E.; US
THOMPSON, Matthew P.; US
DITRI, Treffly; US
BERTIN, Paul A.; US
Agent:
DAILEY, Robert S.; US
Priority Data:
62/491,15927.04.2017US
Title (EN) MODIFIED MRI CONTRAST AGENTS AND USES THEREOF
(FR) PRODUITS DE CONTRASTE POUR IRM MODIFIÉS ET LEURS UTILISATION
Abstract:
(EN) The present disclosure generally provides compounds useful as MRI contrast agents. In some aspects, the disclosure provides MRI contrast agents that are chemically modified to have one or more moieties that include hydrophobic portions. In some aspects, the disclosure provides compositions that include such modified MRI contrast agents and a protein, such as albumin or albumin mimetics. Further, the disclosure provides various uses of these compounds and compositions.
(FR) L'invention concerne d'une manière générale des composés utiles en tant que produits de contraste pour IRM. Dans certains aspects, l'invention concerne des produits de contraste pour IRM qui sont modifiés chimiquement pour comporter au moins une fraction qui comprend des parties hydrophobes. Dans certains aspects, l'invention concerne des compositions qui comprennent de tels produits de contraste pour IRM modifiés et une protéine, telle que l'albumine ou des mimétiques de l'albumine. L'invention concerne en outre diverses utilisations de ces composés et compositions.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)