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1. (WO2018200583) CELLS EXPRESSING CHIMERIC ACTIVATING RECEPTORS AND CHIMERIC STIMULATING RECEPTORS AND USES THEREOF

Pub. No.:    WO/2018/200583    International Application No.:    PCT/US2018/029218
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Wed Apr 25 01:59:59 CEST 2018
IPC: A61K 35/17
A61P 35/00
C07K 14/725
C07K 16/30
C07K 19/00
C12N 5/0783
Applicants: EUREKA THERAPEUTICS, INC.
Inventors: LIU, Hong
ZHANG, Pengbo
HORAN, Lucas
XU, Yiyang
STALEY, Binnaz K.
LIU, Lianxing
YUN, Hongruo
Title: CELLS EXPRESSING CHIMERIC ACTIVATING RECEPTORS AND CHIMERIC STIMULATING RECEPTORS AND USES THEREOF
Abstract:
The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.